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Identification of cervical cancer markers using cDNA subtraction approach.
Eur J Gynaecol Oncol ; 36(6): 730-3, 2015.
Article em En | MEDLINE | ID: mdl-26775362
PURPOSE OF INVESTIGATION: Cervical cancer markers are not well known for accurate detection of the disease. MATERIALS AND METHODS: In the present study, cervical cancer samples were collected from the 42 patients in the Department of Surgery and Medicine of Weifang People's Hospital and Medical College, Shandong, China. The cDNA subtraction approach was performed to find out the specific transcripts, which are responsible for cervical cancer. The specific differentially expressed transcripts were identified by Basic Local Alignment Search Tool (BLAST) analysis and the results were validated by immunohistochemistry. RESULTS: Following differentially expressed specific transcripts, such as ID-1, Hif 1a, and the Y-box were usefully employed as a marker to accurately detect cervical cancer. CONCLUSION. The identified markers are promising in the accurate detection of cervical cancer in terms of its molecular basis and management of the disease.
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Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Neoplasias do Colo do Útero Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Eur J Gynaecol Oncol Ano de publicação: 2015 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Neoplasias do Colo do Útero Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Female / Humans Idioma: En Revista: Eur J Gynaecol Oncol Ano de publicação: 2015 Tipo de documento: Article