Global informatics and physical property selection in protein sequences.
Proc Natl Acad Sci U S A
; 113(7): 1808-10, 2016 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-26831093
ABSTRACT
The degree of informatic independence between the physical properties of amino acids as encoded in actual protein sequences is calculated. It is shown that no physical property can be identified that carries significantly less information than others and that the information overlap between different properties and different length scales along the sequence is essentially zero. These observations suggest that bioinformatic models based on arbitrarily selected sets of physical properties are inherently deficient.
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1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Biologia Computacional
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2016
Tipo de documento:
Article