Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.
Stem Cells
; 34(6): 1702-7, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26991945
ABSTRACT
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;341702-1707.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Neoplasias Encefálicas
/
Glioblastoma
Limite:
Humans
Idioma:
En
Revista:
Stem Cells
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos