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Epidemiology and Outcomes of Congenital Diaphragmatic Hernia in Croatia: A Population-Based Study.
Grizelj, Ruza; Bojanic, Katarina; Vukovic, Jurica; Novak, Milivoj; Rodin, Urelija; Coric, Tanja; Stanojevic, Milan; Schroeder, Darrell R; Weingarten, Toby N; Sprung, Juraj.
Afiliação
  • Grizelj R; Department of Pediatrics, School of Medicine, University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia.
  • Bojanic K; Division of Neonatology, Department of Obstetrics and Gynecology, University Hospital Merkur, Zagreb, Croatia.
  • Vukovic J; Department of Pediatrics, School of Medicine, University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia.
  • Novak M; Department of Pediatrics, School of Medicine, University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia.
  • Rodin U; School of Public Health "A. Stampar" and Croatian Institute of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Coric T; School of Public Health "A. Stampar" and Croatian Institute of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Stanojevic M; Department of Obstetrics and Gynecology, University Hospital Sveti Duh, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Schroeder DR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
  • Weingarten TN; Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Sprung J; Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
Paediatr Perinat Epidemiol ; 30(4): 336-45, 2016 07.
Article em En | MEDLINE | ID: mdl-27016030
BACKGROUND: Outcomes of neonates with congenital diaphragmatic hernia (CDH) are variable; reports are frequently limited to the experience of single tertiary care centres-a possible source of bias. Population-based studies decrease survivor bias and provide additional insight into this high-mortality condition. The objective of this study was to examine the incidence and outcomes of CDH in Croatia. METHODS: All cases of CDH in Croatia from 2001 through 2013 were ascertained from public health records. Overall and sex- and region-specific incidence rates were calculated, and characteristics associated with 1-year survival were assessed. RESULTS: We identified 145 cases of CDH during the study period, for an incidence of 2.67 per 10 000 total births. The incidence did not differ by calendar year (P = 0.38) or geographic region (P = 0.67). There was a slightly higher incidence among males (rate ratio, 1.37, 95% CI 0.99, 1.91). The 1-year survival rate was 33.1% for the entire cohort and 47.9% for liveborns who received any treatment at an intensive care unit. From multivariable analysis, survival was decreased in neonates with left CDH, liver up (odds ratio 0.1, 95% CI, 0.03, 0.4) and increased when treated in a centre with higher case volume (odds ratio 12.8, 95% CI, 2.2, 72.1). CONCLUSIONS: The incidence of CDH in Croatia is within the range of previous reports. Survival was substantially higher in neonates treated in a centre with higher case volume, which suggests that centralisation of medical care for CDH may be warranted in Croatia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diagnóstico Pré-Natal / Hérnias Diafragmáticas Congênitas Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Newborn País/Região como assunto: Europa Idioma: En Revista: Paediatr Perinat Epidemiol Assunto da revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Croácia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diagnóstico Pré-Natal / Hérnias Diafragmáticas Congênitas Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Female / Humans / Male / Newborn País/Região como assunto: Europa Idioma: En Revista: Paediatr Perinat Epidemiol Assunto da revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Croácia