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Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Lu, Chao; Jain, Siddhant U; Hoelper, Dominik; Bechet, Denise; Molden, Rosalynn C; Ran, Leili; Murphy, Devan; Venneti, Sriram; Hameed, Meera; Pawel, Bruce R; Wunder, Jay S; Dickson, Brendan C; Lundgren, Stefan M; Jani, Krupa S; De Jay, Nicolas; Papillon-Cavanagh, Simon; Andrulis, Irene L; Sawyer, Sarah L; Grynspan, David; Turcotte, Robert E; Nadaf, Javad; Fahiminiyah, Somayyeh; Muir, Tom W; Majewski, Jacek; Thompson, Craig B; Chi, Ping; Garcia, Benjamin A; Allis, C David; Jabado, Nada; Lewis, Peter W.
Afiliação
  • Lu C; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
  • Jain SU; Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  • Hoelper D; Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  • Bechet D; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Molden RC; Epigenetics Program and Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
  • Ran L; Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Murphy D; Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Venneti S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Hameed M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Pawel BR; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wunder JS; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Department of Surgical Oncology and Division of Orthopedic Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario M5T 2M9, Canada.
  • Dickson BC; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
  • Lundgren SM; Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA.
  • Jani KS; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
  • De Jay N; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Papillon-Cavanagh S; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Andrulis IL; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Can
  • Sawyer SL; Department of Medical Genetics and Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada.
  • Grynspan D; Department of Medical Genetics and Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada.
  • Turcotte RE; Division of Orthopaedic Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada.
  • Nadaf J; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Fahiminiyah S; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Muir TW; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
  • Majewski J; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada.
  • Thompson CB; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Chi P; Human Oncology and Pathogenesis Program and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  • Garcia BA; Epigenetics Program and Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA. plewis@discovery.wisc.edu nada.jabado@mcgill.ca alliscd@rockefeller.edu.
  • Jabado N; Department of Human Genetics, McGill University, Montreal, Quebec H3Z 2Z3, Canada. Department of Pediatrics, McGill University, Montreal, Quebec H3Z 2Z3, Canada. plewis@discovery.wisc.edu nada.jabado@mcgill.ca alliscd@rockefeller.edu.
  • Lewis PW; Epigenetics Theme, Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI 53715, USA. Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA. plewis@discovery.wisc.edu nada.jabado@mcgill.ca alliscd@rockefeller.edu.
Science ; 352(6287): 844-9, 2016 May 13.
Article em En | MEDLINE | ID: mdl-27174990
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / Células-Tronco Neoplásicas / Neoplasias Ósseas / Histonas / Condroblastoma / Células-Tronco Mesenquimais / Carcinogênese Tipo de estudo: Prognostic_studies Limite: Animals / Child, preschool / Humans Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / Células-Tronco Neoplásicas / Neoplasias Ósseas / Histonas / Condroblastoma / Células-Tronco Mesenquimais / Carcinogênese Tipo de estudo: Prognostic_studies Limite: Animals / Child, preschool / Humans Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos