Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes.

Rajan, Meenu Rohini; Nyman, Elin; Kjølhede, Preben; Cedersund, Gunnar; Strålfors, Peter

Rajan, Meenu Rohini; Nyman, Elin; Kjølhede, Preben; Cedersund, Gunnar; Strålfors, Peter.

Afiliação

Rajan MR; From the Departments of Clinical and Experimental Medicine and.
Nyman E; Biomedical Engineering, Linköping University, SE58185 Linköping, Sweden and Cardiovascular and Metabolic Diseases, Innovative Medicines, and Drug Metabolism and Pharmacokinetics, AstraZeneca Research and Development, 43150 Gothenburg, Sweden.
Kjølhede P; From the Departments of Clinical and Experimental Medicine and.
Cedersund G; From the Departments of Clinical and Experimental Medicine and Biomedical Engineering, Linköping University, SE58185 Linköping, Sweden and.
Strålfors P; From the Departments of Clinical and Experimental Medicine and peter.stralfors@liu.se.

J Biol Chem ; 291(30): 15806-19, 2016 07 22.

Article em En | MEDLINE | ID: mdl-27226562

Assuntos

Adipócitos/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Proteína Forkhead Box O1/metabolismo; Insulina/metabolismo; Modelos Biológicos; Transdução de Sinais; Adipócitos/patologia; Células Cultivadas; Diabetes Mellitus Tipo 2/patologia; Feminino; Proteínas Ativadoras de GTPase/metabolismo; Transportador de Glucose Tipo 4/metabolismo; Humanos; Proteínas Substratos do Receptor de Insulina/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina; Complexos Multiproteicos/metabolismo; Fosforilação; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

adipocyte; human; insulin resistance; insulin signaling; mammalian target of rapamycin (mTOR); mathematical modeling; protein phosphorylation; ribosome biogenesis; transcription factor; type 2 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Adipócitos / Diabetes Mellitus Tipo 2 / Proteína Forkhead Box O1 / Insulina / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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