Hospitalization for musculoskeletal disorders in rheumatoid arthritis patients: a population-based study.
BMC Musculoskelet Disord
; 17: 298, 2016 07 19.
Article
em En
| MEDLINE
| ID: mdl-27431503
ABSTRACT
BACKGROUND:
Rheumatoid arthritis (RA) patients failing disease modifying antirheumatic drugs (DMARDs) may undergo anti-Tumor Necrosis Factor (anti-TNF) therapy. Using the Quebec health services administrative databases, we examined the rates of musculoskeletal (MSD)-related hospitalizations among RA patients receiving anti-TNF, DMARDs, and neither of those therapies (non-users).METHODS:
Matched cohort analyses were performed separately in 2002-2006 and 2007-2011. In each cohort, DMARD and non-user groups were formed to 3-1 match the anti-TNF users on age, sex, date of RA diagnosis, high-dimensional propensity score and date of the first anti-TNF dispensation (index-date). Non-users did not use DMARDs or anti-TNF drugs during the year before the index-date and in the 90 days post, but used at least one of these medications in the study period.RESULTS:
During 2002-2006, 557 anti-TNF users were matched to 1144 DMARD users and to 656 non-users, compared to 690, 1651, and 532 patients, respectively during 2007-2011. The crude rates of MSD-related hospitalizations in the anti-TNF, DMARD and non-users groups were respectively 8.2/100, 6.4/100 and 10.5/100 patient-years in 2002-2006, and 6.9/100, 4.8/100, and 8.6/100 patient-years in 2007-2011. In multivariable Cox regression models, the hazard ratios of MSD-related hospitalizations (95 % confidence interval) were 0.95 (0.60; 1.50) for anti-TNF and 0.69 (0.46; 1.02) for DMARD users, versus non-users in 2002-06, and 0.65 (0.37; 1.14) and 0.40 (0.24; 0.66), respectively in 2007-2011.CONCLUSION:
The MSD-related hospitalization risk was lower in RA patients using DMARD therapy and similar in those using anti-TNF therapy with or without DMARDs as compared to those not using either of these therapies during the study period.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Fator de Necrose Tumoral alfa
/
Doenças Musculoesqueléticas
/
Antirreumáticos
/
Hospitalização
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
BMC Musculoskelet Disord
Assunto da revista:
FISIOLOGIA
/
ORTOPEDIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Canadá