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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
Kung, Pei-Pei; Rui, Eugene; Bergqvist, Simon; Bingham, Patrick; Braganza, John; Collins, Michael; Cui, Mei; Diehl, Wade; Dinh, Dac; Fan, Connie; Fantin, Valeria R; Gukasyan, Hovhannes J; Hu, Wenyue; Huang, Buwen; Kephart, Susan; Krivacic, Cody; Kumpf, Robert A; Li, Gary; Maegley, Karen A; McAlpine, Indrawan; Nguyen, Lisa; Ninkovic, Sacha; Ornelas, Martha; Ryskin, Michael; Scales, Stephanie; Sutton, Scott; Tatlock, John; Verhelle, Dominique; Wang, Fen; Wells, Peter; Wythes, Martin; Yamazaki, Shinji; Yip, Brian; Yu, Xiu; Zehnder, Luke; Zhang, Wei-Guo; Rollins, Robert A; Edwards, Martin.
Afiliação
  • Ryskin M; Pfizer Global Research and Development , 401 North Middletown Road, Pearl River, New York 10965, United States.
  • Zhang WG; Pfizer Global Research and Development , 401 North Middletown Road, Pearl River, New York 10965, United States.
  • Rollins RA; Pfizer Global Research and Development , 401 North Middletown Road, Pearl River, New York 10965, United States.
J Med Chem ; 59(18): 8306-25, 2016 Sep 22.
Article em En | MEDLINE | ID: mdl-27512831
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Desenho de Fármacos / Proteína Potenciadora do Homólogo 2 de Zeste / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Desenho de Fármacos / Proteína Potenciadora do Homólogo 2 de Zeste / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article