IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.
Arch Virol
; 161(11): 3263-8, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27558125
ABSTRACT
This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Infecções por HIV
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Interleucinas
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Perfilação da Expressão Gênica
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Genótipo
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Fatores Imunológicos
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália