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IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.
Monteleone, Katia; Scheri, Giuseppe Corano; Statzu, Maura; Selvaggi, Carla; Falasca, Francesca; Giustini, Noemi; Mezzaroma, Ivano; Turriziani, Ombretta; d'Ettorre, Gabriella; Antonelli, Guido; Scagnolari, Carolina.
Afiliação
  • Monteleone K; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Scheri GC; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Statzu M; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Selvaggi C; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Falasca F; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Giustini N; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Mezzaroma I; Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
  • Turriziani O; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Antonelli G; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy.
  • Scagnolari C; Laboratory of Virology, Department of Molecular Medicine, Istituto Pasteur Italia-Cenci Bolognetti Fondazione, Sapienza University of Rome, Viale di Porta Tiburtina n° 28, 00185, Rome, Italy. carolina.scagnolari@uniroma1.it.
Arch Virol ; 161(11): 3263-8, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27558125
ABSTRACT
This study aimed to evaluate the association between the IFNL4 rs368234815 (ΔG/TT) dinucleotide polymorphism and the IFN response during chronic HIV-1 infection. We carried out genotyping analysis and measured the expression of IFN-stimulated genes (ISGs) (myxovirus resistance protein A [MxA], ISG15, ISG56, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like [APOBEC] 3F and APOBEC3G) on peripheral blood mononuclear cells collected from naïve and HAART-treated HIV-1-infected patients. There were no statistically significant differences in endogenous ISGs mRNA levels among HIV-1-positive patients bearing different IFNL4 genotypes, suggesting that ISG expression is independent of the IFNL4 genotype in HIV-1 infection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / Interleucinas / Perfilação da Expressão Gênica / Genótipo / Fatores Imunológicos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Virol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Infecções por HIV / Interleucinas / Perfilação da Expressão Gênica / Genótipo / Fatores Imunológicos Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Virol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália