Effectiveness and safety of an abacavir/lamivudineâ+ârilpivirine regimen for the treatment of HIV-1 infection in naive patients.
J Antimicrob Chemother
; 71(12): 3510-3514, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27591292
ABSTRACT
OBJECTIVES:
To describe the effectiveness and safety of an abacavir/lamivudineâ+ârilpivirine regimen in naive HIV-1-infected patients, as there is a lack of data with this combination.METHODS:
This was an observational, retrospective, multicentre study in eight Spanish hospitals. All antiretroviral-naive patients ≥18 years old and starting abacavir/lamivudineâ+ârilpivirine were included. Effectiveness (ITT and on-treatment) and safety (adverse events and laboratory parameters) were assessed during follow-up. Values are expressed as n (%) or median (IQR). The Wilcoxon signed-rank test was used to compare baseline and 6 and 12 month values.RESULTS:
Eighty-four patients were included [93% males, ageâ=â36 (30-45) years]. Time since HIV diagnosis was 12 (4-35) months. Fifty-one per cent of patients had comorbidities. Baseline CD4+ was 425 (340-519) cells/mm3 and baseline HIV-RNA was 19â000 (9500-42â000) copies/mL. Median follow-up was 18 (9-22) months; 100% and 68% patients with at least 6 and 12 months, respectively. At 6 and 12 months effectiveness was 94% and 86% by ITT analysis and 96% and 97% by on-treatment analysis. At 12 months, there were significant increases in CD4+ (+262 cell/mm3) and HDL cholesterol (+4 mg/dL) and a significant decrease in the total cholesterol/HDL cholesterol ratio (-0.2). There were two (2.4%) virological failures (HIV-RNA 50-100 copies/mL); one patient later achieving virological suppression without changing the treatment. Six patients (7.1%) changed treatment due to reasons other than virological failure or side effects. One patient discontinued treatment due to gastrointestinal complaints attributed to abacavir/lamivudine.CONCLUSIONS:
Abacavir/lamivudineâ+ârilpivirine was an effective and safe option in a selected group of HIV-1-infected treatment-naive patients.
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Base de dados:
MEDLINE
Assunto principal:
Didesoxinucleosídeos
/
Infecções por HIV
/
Lamivudina
/
Fármacos Anti-HIV
/
Rilpivirina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Espanha