S100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection.
Maxillofac Plast Reconstr Surg
; 38(1): 33, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27635391
ABSTRACT
BACKGROUND:
The purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).METHODS:
We injected either 5 or 10 U of BTX-A into both masseter muscle of rats. As a control group, the same volume of saline was injected. After 14 days, the animals were sacrificed. Subsequently, a biopsy and immunohistochemical staining of the samples were performed using a p65 or S100 antibody.RESULTS:
The cross-sectional area of each myofibril was significantly reduced by BTX-A injection (P < 0.001). The expression of p65 and S100 increased significantly with increasing concentrations of BTX-A (P < 0.001).CONCLUSIONS:
The injection of BTX-A into the masseter muscle induced muscle atrophy. Subsequently, p65 and S100 expression in myoblasts were increased for the protection of muscle cells.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Maxillofac Plast Reconstr Surg
Ano de publicação:
2016
Tipo de documento:
Article