Emerging Treatments for Heterozygous and Homozygous Familial Hypercholesterolemia.
Rev Cardiovasc Med
; 17(1-2): 16-27, 2016.
Article
em En
| MEDLINE
| ID: mdl-27667377
ABSTRACT
Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder marked by extremely high low-density lipoprotein (LDL) cholesterol levels and concomitant premature vascular disease. FH is caused by mutations that most commonly affect three genes integrally involved in the LDL receptor's ability to clear LDL particles from the circulation. Primary intervention efforts to lower LDL cholesterol have centered on therapies that upregulate the LDL receptor. Unfortunately, most patients are insufficiently responsive to traditional LDL-lowering medications. This article focuses primarily on the clinical management of homozygous FH.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hiperlipoproteinemia Tipo II
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Rev Cardiovasc Med
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article