Clinical trials with cholesteryl ester transfer protein inhibitors.
Curr Opin Lipidol
; 27(6): 545-549, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27676199
ABSTRACT
PURPOSE OF REVIEW Inhibition of cholesteryl ester transfer protein (CETP) has received considerable interest by virtue of its favorable effects on atherogenic and protective lipid parameters. The impact of CETP inhibitors in large clinical outcome trials will be reviewed. RECENT FINDINGS:
Population and genetic studies demonstrate that low CETP activity associates with lower rates of cardiovascular events. Inhibiting CETP activity in animal models has a favorable impact on experimental atherosclerosis. Although the first CETP inhibitor to advance to an outcome trial proved to have adverse clinical effects and the next agent, a more modest inhibitor, was clinically futile, there continues to be immense interest in the potential to develop nontoxic, potent CETP inhibitors to reduce cardiovascular risk.SUMMARY:
The current status of CETP inhibitors in the context of large outcomes trials will be reviewed.
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Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos como Assunto
/
Proteínas de Transferência de Ésteres de Colesterol
/
Anticolesterolemiantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Lipidol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália