Cathepsin S contributes to microglia-mediated olfactory dysfunction through the regulation of Cx3cl1-Cx3cr1 axis in a Niemann-Pick disease type C1 model.

Seo, Yoojin; Kim, Hyung-Sik; Kang, Insung; Choi, Soon Won; Shin, Tae-Hoon; Shin, Ji-Hee; Lee, Byung-Chul; Lee, Jin Young; Kim, Jae-Jun; Kook, Myung Geun; Kang, Kyung-Sun

Seo, Yoojin; Kim, Hyung-Sik; Kang, Insung; Choi, Soon Won; Shin, Tae-Hoon; Shin, Ji-Hee; Lee, Byung-Chul; Lee, Jin Young; Kim, Jae-Jun; Kook, Myung Geun; Kang, Kyung-Sun.

Afiliação

Seo Y; Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Kim HS; School of Medicine, Pusan National University, Busan, 49241, South Korea.
Kang I; Biomedical Research Institute, Pusan National University Hospital, Busan, 49241, South Korea.
Choi SW; Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Shin TH; School of Medicine, Pusan National University, Busan, 49241, South Korea.
Shin JH; Biomedical Research Institute, Pusan National University Hospital, Busan, 49241, South Korea.
Lee BC; Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Lee JY; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Kim JJ; Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Kook MG; Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.
Kang KS; Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South Korea.

Glia ; 64(12): 2291-2305, 2016 12.

Article em En | MEDLINE | ID: mdl-27687148

Assuntos

Receptor 1 de Quimiocina CX3C/metabolismo; Catepsinas/metabolismo; Quimiocina CX3CL1/metabolismo; Microglia/metabolismo; Doença de Niemann-Pick Tipo A/complicações; Transtornos do Olfato/etiologia; Transtornos do Olfato/patologia; Animais; Receptor 1 de Quimiocina CX3C/genética; Proteínas de Ligação ao Cálcio/metabolismo; Células Cultivadas; Quimiocina CX3CL1/genética; Modelos Animais de Doenças; Comportamento Alimentar; Técnicas In Vitro; Peptídeos e Proteínas de Sinalização Intracelular; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Transgênicos; Proteínas dos Microfilamentos/metabolismo; Proteína C1 de Niemann-Pick; Doença de Niemann-Pick Tipo A/genética; Bulbo Olfatório/citologia; Técnicas de Cultura de Órgãos; Proteínas/genética; Proteínas/metabolismo; Transdução de Sinais/genética; Regulação para Cima/genética

Palavras-chave

Cathepsin S; Cx3cl1-Cx3cr1 interaction; Niemann-Pick disease type C; microglia; olfaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catepsinas / Microglia / Doença de Niemann-Pick Tipo A / Quimiocina CX3CL1 / Receptor 1 de Quimiocina CX3C / Transtornos do Olfato Limite: Animals Idioma: En Revista: Glia Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Coréia do Sul

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