Desmoplastic melanoma: a challenge for the oncologist.
Future Oncol
; 13(4): 337-345, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27728982
ABSTRACT
AIM:
To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM). MATERIALS &METHODS:
Analysis of all DM records from 1991 to 2015.RESULTS:
The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4.5 mm) was observed in 'pure' DM.CONCLUSION:
DM could progress from an early phase, characterized by an intraepidermal component, to late phase, characterized by a dermal nodule. This hypothesis correlates with melanoma genetic and NF1 mutation, which could be an early event in the progression of DM.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Melanoma
Limite:
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Itália