A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.

Ray, Lauren; Valentic, Timothy R; Miyazawa, Takeshi; Withall, David M; Song, Lijiang; Milligan, Jacob C; Osada, Hiroyuki; Takahashi, Shunji; Tsai, Shiou-Chuan; Challis, Gregory L

Ray, Lauren; Valentic, Timothy R; Miyazawa, Takeshi; Withall, David M; Song, Lijiang; Milligan, Jacob C; Osada, Hiroyuki; Takahashi, Shunji; Tsai, Shiou-Chuan; Challis, Gregory L.

Afiliação

Ray L; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Valentic TR; Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, California 92697, USA.
Miyazawa T; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.
Withall DM; Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Song L; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Milligan JC; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Osada H; Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, California 92697, USA.
Takahashi S; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.
Tsai SC; Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.
Challis GL; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.

Nat Commun ; 7: 13609, 2016 12 21.

Article em En | MEDLINE | ID: mdl-28000660

Assuntos

Acil Coenzima A/metabolismo; Proteínas de Bactérias/metabolismo; Policetídeo Sintases/metabolismo; Policetídeos/metabolismo; Acil Coenzima A/química; Acil Coenzima A/genética; Acil-CoA Desidrogenases/metabolismo; Sequência de Aminoácidos; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Carbono-Carbono Ligases/metabolismo; Cristalografia por Raios X; Modelos Moleculares; Estrutura Molecular; Policetídeo Sintases/química; Policetídeo Sintases/genética; Policetídeos/química; Conformação Proteica; Homologia de Sequência de Aminoácidos; Streptomyces/genética; Streptomyces/metabolismo; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Acil Coenzima A / Policetídeo Sintases / Policetídeos Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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