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Two new coumarins from the bark of Streblus indicus (Bur.) Corner.
He, Ruijie; Deng, Shengping; Nie, Hui; Huang, Yan; Liu, Buming; Yang, Ruiyun; Huang, Shuai; Zhou, Dexiong; Chen, Huangcan; Li, Jun; Zhang, Yanjun.
Afiliação
  • He R; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Deng S; b Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization , Guangxi Institute of Botany , Guilin , P.R. China.
  • Nie H; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Huang Y; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Liu B; c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands , Guangxi Insitute of Chinese Medicine & Pharmaceutical Science , Nanning , P.R. China.
  • Yang R; c Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands , Guangxi Insitute of Chinese Medicine & Pharmaceutical Science , Nanning , P.R. China.
  • Huang S; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Zhou D; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Chen H; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Li J; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
  • Zhang Y; a State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy , Guangxi Normal University , Guilin , P.R. China.
Nat Prod Res ; 31(9): 1052-1058, 2017 May.
Article em En | MEDLINE | ID: mdl-28013566
ABSTRACT
Two new coumarins 7-O-(6-O-(5-O-3,4,5-tri-methoxycinnamate-ß-d-apiofuranosyl-ß-d-glucopyranosyl)-6-methoxy coumarin (1) and 7-O-(6-O-(4-(2-hydroxy-1-hydroxymethyl-ethoxy)-3-methoxy-cinnamyl)-ß-d-glucopyranosyl)-6-methoxy coumarin (2), along with 10 known metabolites, were isolated from the bark of Streblus indicus, their structures were identified by comparison of experimental and published spectroscopic data. (S)-marmesinin (6) and scoparone (7) exhibited moderate antimicrobial activity in vitro against Staphylococcus aureus strain with the MIC values of 62.5 and 125.0 µg/mL, respectively. Betulinic acid showed inhibitory activity in vitro against MCF-7 cell with IC50 value of 9.5 ± 0.1 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cumarínicos / Moraceae Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cumarínicos / Moraceae Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2017 Tipo de documento: Article