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Systemic Immunity Is Required for Effective Cancer Immunotherapy.
Spitzer, Matthew H; Carmi, Yaron; Reticker-Flynn, Nathan E; Kwek, Serena S; Madhireddy, Deepthi; Martins, Maria M; Gherardini, Pier Federico; Prestwood, Tyler R; Chabon, Jonathan; Bendall, Sean C; Fong, Lawrence; Nolan, Garry P; Engleman, Edgar G.
Afiliação
  • Spitzer MH; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Baxter Lab in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Program in Immunology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunol
  • Carmi Y; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Department of Pathology, The Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel.
  • Reticker-Flynn NE; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Kwek SS; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Madhireddy D; Baxter Lab in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Martins MM; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Gherardini PF; Baxter Lab in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Prestwood TR; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Chabon J; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Bendall SC; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Fong L; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Nolan GP; Baxter Lab in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Program in Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: gnolan@stanford.edu.
  • Engleman EG; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Program in Immunology, Stanford University, Stanford, CA 94305, USA. Electronic address: edengleman@stanford.edu.
Cell ; 168(3): 487-502.e15, 2017 01 26.
Article em En | MEDLINE | ID: mdl-28111070
Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos T / Imunoterapia / Neoplasias Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos T / Imunoterapia / Neoplasias Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article