Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.
Nat Commun
; 8: 14155, 2017 01 27.
Article
em En
| MEDLINE
| ID: mdl-28128201
ABSTRACT
The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophysiology. Mechanical disruption or pharmacological blockade of parasympathetic innervation shortens ventricular refractory periods, increases the incidence of ventricular arrhythmia and decreases ventricular cAMP levels in murine hearts. Immunohistochemistry confirmed ventricular cholinergic innervation, revealing parasympathetic fibres running from the atria to the ventricles parallel to sympathetic fibres. In humans, catheter ablation of atrial fibrillation, which is accompanied by accidental parasympathetic and concomitant sympathetic denervation, raises the burden of premature ventricular complexes. In summary, our results demonstrate an influence of cardiac cholinergic neurons on the regulation of ventricular function and arrhythmogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Parassimpático
/
Fibrilação Atrial
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Ablação por Cateter
/
Neurônios Colinérgicos
/
Ventrículos do Coração
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Nat Commun
Assunto da revista:
BIOLOGIA
/
CIENCIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha