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Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.
George, Suzanne; Miao, Diana; Demetri, George D; Adeegbe, Dennis; Rodig, Scott J; Shukla, Sachet; Lipschitz, Mikel; Amin-Mansour, Ali; Raut, Chandrajit P; Carter, Scott L; Hammerman, Peter; Freeman, Gordon J; Wu, Catherine J; Ott, Patrick A; Wong, Kwok-Kin; Van Allen, Eliezer M.
Afiliação
  • George S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Miao D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Demetri GD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA.
  • Adeegbe D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Shukla S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Lipschitz M; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.
  • Amin-Mansour A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Raut CP; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02215, USA.
  • Carter SL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Hammerman P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Ott PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Wong KK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: eliezerm_vanallen@dfci.harvard.edu.
Immunity ; 46(2): 197-204, 2017 02 21.
Article em En | MEDLINE | ID: mdl-28228279
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Resistencia a Medicamentos Antineoplásicos / PTEN Fosfo-Hidrolase / Leiomiossarcoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Resistencia a Medicamentos Antineoplásicos / PTEN Fosfo-Hidrolase / Leiomiossarcoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos