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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.
Huang, Alexander C; Postow, Michael A; Orlowski, Robert J; Mick, Rosemarie; Bengsch, Bertram; Manne, Sasikanth; Xu, Wei; Harmon, Shannon; Giles, Josephine R; Wenz, Brandon; Adamow, Matthew; Kuk, Deborah; Panageas, Katherine S; Carrera, Cristina; Wong, Phillip; Quagliarello, Felix; Wubbenhorst, Bradley; D'Andrea, Kurt; Pauken, Kristen E; Herati, Ramin S; Staupe, Ryan P; Schenkel, Jason M; McGettigan, Suzanne; Kothari, Shawn; George, Sangeeth M; Vonderheide, Robert H; Amaravadi, Ravi K; Karakousis, Giorgos C; Schuchter, Lynn M; Xu, Xiaowei; Nathanson, Katherine L; Wolchok, Jedd D; Gangadhar, Tara C; Wherry, E John.
Afiliação
  • Huang AC; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Postow MA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Orlowski RJ; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Mick R; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bengsch B; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Manne S; Weill Cornell Medical College, New York, New York, USA.
  • Xu W; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Harmon S; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Giles JR; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wenz B; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Adamow M; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kuk D; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Panageas KS; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Carrera C; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wong P; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Quagliarello F; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wubbenhorst B; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • D'Andrea K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Pauken KE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Herati RS; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Staupe RP; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Schenkel JM; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • McGettigan S; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kothari S; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • George SM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Vonderheide RH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Amaravadi RK; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Karakousis GC; Immune Monitoring Facility, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Schuchter LM; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Xu X; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Nathanson KL; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Wolchok JD; Department of Dermatology, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.
  • Gangadhar TC; Immune Monitoring Facility, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Wherry EJ; Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nature ; 545(7652): 60-65, 2017 05 04.
Article em En | MEDLINE | ID: mdl-28397821
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Carga Tumoral / Receptor de Morte Celular Programada 1 / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Carga Tumoral / Receptor de Morte Celular Programada 1 / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos