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A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization.
Drent, Esther; Themeli, Maria; Poels, Renée; de Jong-Korlaar, Regina; Yuan, Huipin; de Bruijn, Joost; Martens, Anton C M; Zweegman, Sonja; van de Donk, Niels W C J; Groen, Richard W J; Lokhorst, Henk M; Mutis, Tuna.
Afiliação
  • Drent E; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Themeli M; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Poels R; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • de Jong-Korlaar R; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Yuan H; Xpand Biotechnology BV, Professor Bronkhorstlaan 10-D, 3723MB Bilthoven, the Netherlands.
  • de Bruijn J; Xpand Biotechnology BV, Professor Bronkhorstlaan 10-D, 3723MB Bilthoven, the Netherlands; The School of Engineering and Materials Science, Queen Mary University of London, Mile End Rd., London E1 4NS, UK.
  • Martens ACM; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Zweegman S; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • van de Donk NWCJ; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Groen RWJ; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Lokhorst HM; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands.
  • Mutis T; Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, the Netherlands. Electronic address: t.mutis@vumc.nl.
Mol Ther ; 25(8): 1946-1958, 2017 08 02.
Article em En | MEDLINE | ID: mdl-28506593
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Receptores de Antígenos de Linfócitos T / ADP-Ribosil Ciclase 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Receptores de Antígenos de Linfócitos T / ADP-Ribosil Ciclase 1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda