[Involvement of aquaporin-4 in synaptic plasticity, learning and memory].
Sheng Li Xue Bao
; 69(3): 335-343, 2017 Jun 25.
Article
em Zh
| MEDLINE
| ID: mdl-28638927
ABSTRACT
Aquaporin-4 (AQP-4) is the predominant water channel in the central nervous system (CNS) and primarily expressed in astrocytes. Astrocytes have been generally believed to play important roles in regulating synaptic plasticity and information processing. However, the role of AQP-4 in regulating synaptic plasticity, learning and memory, cognitive function is only beginning to be investigated. It is well known that synaptic plasticity is the prime candidate for mediating of learning and memory. Long term potentiation (LTP) and long term depression (LTD) are two forms of synaptic plasticity, and they share some but not all the properties and mechanisms. Hippocampus is a part of limbic system that is particularly important in regulation of learning and memory. This article is to review some research progresses of the function of AQP-4 in synaptic plasticity, learning and memory, and propose the possible role of AQP-4 as a new target in the treatment of cognitive dysfunction.
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Base de dados:
MEDLINE
Assunto principal:
Aquaporina 4
/
Aprendizagem
/
Memória
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China