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Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.
Mateus, André; Gordon, Laurie J; Wayne, Gareth J; Almqvist, Helena; Axelsson, Hanna; Seashore-Ludlow, Brinton; Treyer, Andrea; Matsson, Pär; Lundbäck, Thomas; West, Andy; Hann, Michael M; Artursson, Per.
Afiliação
  • Mateus A; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Gordon LJ; Platform Technology and Science, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom.
  • Wayne GJ; Department of Target and Pathway Validation, GlaxoSmithKline, SG1 2NY Stevenage, United Kingdom.
  • Almqvist H; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.
  • Axelsson H; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden.
  • Seashore-Ludlow B; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.
  • Treyer A; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden.
  • Matsson P; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.
  • Lundbäck T; Department of Medical Biochemistry & Biophysics, Chemical Biology, Karolinska Institute, SE-171 65 Solna, Sweden.
  • West A; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Hann MM; Department of Pharmacy, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Artursson P; Division of Translational Medicine, Laboratories for Chemical Biology, Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institute, SE-171 65 Solna, Sweden.
Proc Natl Acad Sci U S A ; 114(30): E6231-E6239, 2017 07 25.
Article em En | MEDLINE | ID: mdl-28701380
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia