Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing.

Gueroussov, Serge; Weatheritt, Robert J; O'Hanlon, Dave; Lin, Zhen-Yuan; Narula, Ashrut; Gingras, Anne-Claude; Blencowe, Benjamin J

Gueroussov, Serge; Weatheritt, Robert J; O'Hanlon, Dave; Lin, Zhen-Yuan; Narula, Ashrut; Gingras, Anne-Claude; Blencowe, Benjamin J.

Afiliação

Gueroussov S; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: serge.gueroussov@utoronto.ca.
Weatheritt RJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
O'Hanlon D; Donnelly Centre, University of Toronto, Toronto, ON, Canada.
Lin ZY; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Narula A; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Blencowe BJ; Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: b.blencowe@utoronto.ca.

Cell ; 170(2): 324-339.e23, 2017 Jul 13.

Article em En | MEDLINE | ID: mdl-28709000

Assuntos

Processamento Alternativo; Ribonucleoproteínas Nucleares Heterogêneas/metabolismo; Mamíferos/genética; Sequência de Aminoácidos; Animais; Regulação da Expressão Gênica; Humanos; Mamíferos/metabolismo; Isoformas de Proteínas/metabolismo; Precursores de RNA/metabolismo; Alinhamento de Sequência; Vertebrados/genética; Vertebrados/metabolismo

Palavras-chave

alternative splicing; evolution; hnRNP; multivalent assemblies; phase separation; protein disorder

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento Alternativo / Ribonucleoproteínas Nucleares Heterogêneas / Mamíferos Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2017 Tipo de documento: Article

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