Design of modular dual enzyme-responsive peptides.
Biopolymers
; 108(5)2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28799649
ABSTRACT
Dual enzyme-responsive peptides were synthesized by masking the É-amine of lysine with various enzyme substrates. Enzymatic cleavage of these sequences unmasked the É-amine, allowing for further digestion by a second enzyme, which was monitored colorimetrically. This modular peptide design should provide substrates for a large combination of clinically relevant enzymes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Enzimas
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
2017
Tipo de documento:
Article