Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.
J Nat Prod
; 80(9): 2556-2560, 2017 09 22.
Article
em En
| MEDLINE
| ID: mdl-28837335
ABSTRACT
Antibacterial-guided fractionation of an extract of a deep-water Topsentia sp. marine sponge led to the isolation of two new indole alkaloids, tulongicin A (1) and dihydrospongotine C (2), along with two known analogues, spongotine C (3) and dibromodeoxytopsentin (4). Their planar structures were determined by NMR spectroscopy. Their absolute configurations were determined through a combination of experimental and computational analyses. Tulongicin (1) is the first natural product to contain a di(6-Br-1H-indol-3-yl)methyl group linked to an imidazole core. The coexistence of tri-indole 1 and bis-indole alcohol 2 suggests a possible route to 1. All of the compounds showed strong antimicrobial activity against Staphylococcus aureus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Alcaloides Indólicos
/
Imidazóis
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Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos