Diagnosis of Cytomegalovirus Infection during Exacerbation of Ulcerative Colitis.
Digestion
; 96(3): 142-148, 2017.
Article
em En
| MEDLINE
| ID: mdl-28848127
ABSTRACT
BACKGROUND/AIMS:
The role of cytomegalovirus (CMV) reactivation during exacerbations of ulcerative colitis (UC) is yet a matter of debate, and assessment of CMV infection in UC patients remains an ongoing challenge. We aimed to identify associated parameters and compare detection methods for CMV infection during UC exacerbation.METHODS:
Clinical, pathological and virological parameters were retrospectively analyzed in all patients hospitalized in our institution for UC exacerbation between January 2009 and April 2015, who underwent full evaluation for CMV infection in colonic tissue by histopathology, immunohistochemistry (IHC) and CMV-PCR.RESULTS:
Of 28 patients who underwent full examination for tissue CMV-infection, 13 (46.4%) were found to be positive for CMV. Tissue CMV-PCR was more sensitive for the detection of CMV infection than histopathology and IHC. CMV-positive patients had a statistically higher frequency of recent steroid treatment and fever, with higher mean partial Mayo scores and lower mean albumin levels. There were no significant differences between CMV-positive and CMV-negative patients in terms of age, severity of colitis and disease duration. In a multivariable model, only recent steroid treatment and fever were independently associated with colonic CMV infection.CONCLUSIONS:
This study provides a clinical model to detect the presence of CMV infection in patients hospitalized with UC exacerbation, which could direct proper investigation and facilitate timely empirical therapy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
DNA Viral
/
Colite Ulcerativa
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Infecções por Citomegalovirus
/
Citomegalovirus
/
Febre
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Digestion
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos