Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C<sub>2</sub>A domain in asynchronous neurotransmitter release.

Voleti, Rashmi; Tomchick, Diana R; Südhof, Thomas C; Rizo, Josep

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C₂A domain in asynchronous neurotransmitter release.

Voleti, Rashmi; Tomchick, Diana R; Südhof, Thomas C; Rizo, Josep.

Afiliação

Voleti R; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Tomchick DR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Südhof TC; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proc Natl Acad Sci U S A ; 114(40): E8518-E8527, 2017 10 03.

Article em En | MEDLINE | ID: mdl-28923929

Assuntos

Cálcio/metabolismo; Membrana Celular/metabolismo; Neurotransmissores/metabolismo; Sinaptotagmina I/metabolismo; Sinaptotagminas/metabolismo; Animais; Cristalografia por Raios X; Lipossomos; Ligação Proteica; Domínios Proteicos; Ratos; Transmissão Sináptica; Sinaptotagmina I/química; Sinaptotagmina I/genética; Sinaptotagminas/química; Sinaptotagminas/genética

Palavras-chave

X-ray crystallography; membrane binding; neurotransmitter release; synaptotagmin-1; synaptotagmin-7

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Membrana Celular / Cálcio / Neurotransmissores / Sinaptotagminas / Sinaptotagmina I Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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