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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Shi, Yang; Yamada, Kaoru; Liddelow, Shane Antony; Smith, Scott T; Zhao, Lingzhi; Luo, Wenjie; Tsai, Richard M; Spina, Salvatore; Grinberg, Lea T; Rojas, Julio C; Gallardo, Gilbert; Wang, Kairuo; Roh, Joseph; Robinson, Grace; Finn, Mary Beth; Jiang, Hong; Sullivan, Patrick M; Baufeld, Caroline; Wood, Michael W; Sutphen, Courtney; McCue, Lena; Xiong, Chengjie; Del-Aguila, Jorge L; Morris, John C; Cruchaga, Carlos; Fagan, Anne M; Miller, Bruce L; Boxer, Adam L; Seeley, William W; Butovsky, Oleg; Barres, Ben A; Paul, Steven M; Holtzman, David M.
Afiliação
  • Shi Y; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Yamada K; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
  • Liddelow SA; Department of Neurobiology, School of Medicine, Stanford University, Stanford, California 94305, USA.
  • Smith ST; Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, Parkville, Victoria 3010, Australia.
  • Zhao L; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Luo W; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA.
  • Tsai RM; Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA.
  • Spina S; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Grinberg LT; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Rojas JC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Gallardo G; Department of Pathology, University of California, San Francisco, California 94143, USA.
  • Wang K; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Roh J; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Robinson G; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Finn MB; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Jiang H; Department of Ophthalmology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA.
  • Sullivan PM; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Baufeld C; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Wood MW; Department of Medicine, Duke University Medical Center, Durham Veterans Health Administration Medical Center's Geriatric Research, Education and Clinical Center, Durham, North Carolina 27705, USA.
  • Sutphen C; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • McCue L; AstraZeneca R&D, Wilmington, Delaware 19850, USA.
  • Xiong C; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Del-Aguila JL; Division of Biostatistics, Washington University in St Louis, St Louis, Missouri 63110, USA.
  • Morris JC; Division of Biostatistics, Washington University in St Louis, St Louis, Missouri 63110, USA.
  • Cruchaga C; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue B8134, St. Louis, Missouri 63110, USA.
  • Fagan AM; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue B8134, St. Louis, Missouri 63110, USA.
  • Miller BL; Department of Developmental Biology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.
  • Seeley WW; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
  • Butovsky O; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Barres BA; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Paul SM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143 USA.
  • Holtzman DM; Department of Pathology, University of California, San Francisco, California 94143, USA.
Nature ; 549(7673): 523-527, 2017 09 28.
Article em En | MEDLINE | ID: mdl-28959956
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Tauopatias / Apolipoproteína E4 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Tauopatias / Apolipoproteína E4 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos