Inhibition of thromboxane biosynthesis by 3-pyridinol carboxypentyl ethers substituted with a hydroxylated octyl chain.
J Pharm Pharmacol
; 40(2): 144-6, 1988 Feb.
Article
em En
| MEDLINE
| ID: mdl-2897452
ABSTRACT
Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.
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Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Tromboxano B2
/
Tromboxano-A Sintase
Limite:
Humans
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Itália