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The role of cognitive reserve in cognitive aging: what we can learn from Parkinson's disease.
Ciccarelli, Nicoletta; Monaco, Maria Rita Lo; Fusco, Domenico; Vetrano, Davide Liborio; Zuccalà, Giuseppe; Bernabei, Roberto; Brandi, Vincenzo; Pisciotta, Maria Stella; Silveri, Maria Caterina.
Afiliação
  • Ciccarelli N; Department of Psychology, Catholic University, Largo Agostino Gemelli 1, 20123, Milan, Italy. nicoletta.ciccarelli@gmail.com.
  • Monaco MRL; Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
  • Fusco D; Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
  • Vetrano DL; Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
  • Zuccalà G; Karolinska Institute and Stockholm University, Stockholm, Sweden.
  • Bernabei R; Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
  • Brandi V; Catholic University, Rome, Italy.
  • Pisciotta MS; Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
  • Silveri MC; Catholic University, Rome, Italy.
Aging Clin Exp Res ; 30(7): 877-880, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29019160
Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors. At linear regression analyses, higher CR scores were independently associated with a better performance on Word Fluency (p ≤ 0.04) and Digit Span (backward) (p ≤ 0.02); no associations were observed between CR and other cognitive tests. Our data provide empirical support to the relation between CR and cognitive impairment in PD. In particular, this study suggests that CR may have greater effects on the cognitive areas mostly affected in PD as executive functions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Função Executiva / Reserva Cognitiva / Disfunção Cognitiva / Envelhecimento Cognitivo Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Função Executiva / Reserva Cognitiva / Disfunção Cognitiva / Envelhecimento Cognitivo Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália