Regenerating CNS myelin - from mechanisms to experimental medicines.
Nat Rev Neurosci
; 18(12): 753-769, 2017 11 16.
Article
em En
| MEDLINE
| ID: mdl-29142295
ABSTRACT
Although the core concept of remyelination - based on the activation, migration, proliferation and differentiation of CNS progenitors - has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably. We can now decorate the central events of remyelination with a host of pathways, molecules, mediators and cells, revealing a complex and precisely orchestrated process. These advances have led to recent drug-based and cell-based clinical trials for myelin diseases and have opened up hitherto unrecognized opportunities for drug-based approaches to therapeutically enhance remyelination.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligodendroglia
/
Doenças Desmielinizantes
/
Bainha de Mielina
/
Regeneração Nervosa
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido