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The challenges of treating aspergillus abdominal aneurysm after hematopoietic cell transplant: Rapid voriconazole metabolizer.
Wasko, Justin A; Ustun, Celalettin; Birkenbach, Mark; Faizer, Rumi; Green, Jaime S.
Afiliação
  • Wasko JA; 1 Department of Pharmacy, University of Minnesota Medical Center, Minneapolis, MN, USA.
  • Ustun C; 2 Department of Medicine, Division of Hematology-Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.
  • Birkenbach M; 3 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • Faizer R; 4 Department of Surgery, Division of Vascular Surgery, University of Minnesota, Minneapolis, MN, USA.
  • Green JS; 5 Department of Medicine, Division of Infectious Diseases, University of Minnesota, Minneapolis, MN, USA.
J Oncol Pharm Pract ; 25(3): 703-705, 2019 Apr.
Article em En | MEDLINE | ID: mdl-29285995
ABSTRACT
Mycotic aneurysms are a fatal manifestation of disseminated fungal infections in immunocompromised hosts. We present a patient with an Aspergillus mycotic aneurysm after hematopoietic cell transplant. Due to CYP2C19 rapid metabolizer phenotype (*1/*17), therapeutic levels of voriconazole were unobtainable. Successful therapy was achieved with posaconazole salvage therapy and early, aggressive surgery. This case demonstrates the consequences of voriconazole rapid metabolism and the potential impact of genetic variants.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergilose / Triazóis / Aneurisma Infectado / Transplante de Células-Tronco Hematopoéticas / Voriconazol / Antifúngicos Limite: Humans / Male / Middle aged Idioma: En Revista: J Oncol Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergilose / Triazóis / Aneurisma Infectado / Transplante de Células-Tronco Hematopoéticas / Voriconazol / Antifúngicos Limite: Humans / Male / Middle aged Idioma: En Revista: J Oncol Pharm Pract Assunto da revista: FARMACIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos