Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-ß1.

Yang, Zike; Qi, Yanxia; Lai, Nan; Zhang, Jiahe; Chen, Zehong; Liu, Mingyu; Zhang, Wan; Luo, Rongcheng; Kang, Shijun

Yang, Zike; Qi, Yanxia; Lai, Nan; Zhang, Jiahe; Chen, Zehong; Liu, Mingyu; Zhang, Wan; Luo, Rongcheng; Kang, Shijun.

Afiliação

Yang Z; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Qi Y; Cancer Center, The First People's Hospital of Huaihua City, Huaihua, 418000, Hunan Province, People's Republic of China.
Lai N; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Zhang J; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Chen Z; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Liu M; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Zhang W; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China.
Luo R; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, No.13, Shiliugang Road, Haizhu District, Guangzhou, 510315, Guangdong Province, People's Republic of China. luorc02@vip.163.com.
Kang S; Oncology Department, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Baiyun District, Guangzhou, Guangdong Province, 510515, People's Republic of China. kangshijunlb@163.com.

J Exp Clin Cancer Res ; 37(1): 1, 2018 Jan 04.

Article em En | MEDLINE | ID: mdl-29301578

Assuntos

Tolerância Imunológica; Imunomodulação; Melanoma/imunologia; Melanoma/metabolismo; Receptor Notch1/metabolismo; Transdução de Sinais; Fator de Crescimento Transformador beta1/metabolismo; Animais; Apoptose/genética; Biomarcadores; Citotoxicidade Imunológica; Feminino; Expressão Gênica; Sistema Imunitário/imunologia; Sistema Imunitário/metabolismo; Imunofenotipagem; Células Matadoras Naturais/imunologia; Células Matadoras Naturais/metabolismo; Ativação Linfocitária/imunologia; Melanoma/genética; Melanoma/patologia; Melanoma Experimental; Camundongos; Receptor Notch1/genética; Subpopulações de Linfócitos T/imunologia; Subpopulações de Linfócitos T/metabolismo; Carga Tumoral

Palavras-chave

Immunosuppression; Immunotherapy; Malignant melanoma; Notch; Notch1; TGF-ß1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptor Notch1 / Fator de Crescimento Transformador beta1 / Imunomodulação / Tolerância Imunológica / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2018 Tipo de documento: Article

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