Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.

Auguste, Gaelle; Gurha, Priyatansh; Lombardi, Raffaella; Coarfa, Cristian; Willerson, James T; Marian, Ali J

Auguste, Gaelle; Gurha, Priyatansh; Lombardi, Raffaella; Coarfa, Cristian; Willerson, James T; Marian, Ali J.

Afiliação

Auguste G; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.).
Gurha P; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.).
Lombardi R; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.).
Coarfa C; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.).
Willerson JT; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.).
Marian AJ; From the Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston (G.A., P.G., R.L., T.T.W., A.J.M.), Texas Heart Institute (J.T.W., A.J.M.); and Baylor College of Medicine, Houston, TX (C.C.). Ali.J.Marian@

Circ Res ; 122(5): 678-692, 2018 03 02.

Article em En | MEDLINE | ID: mdl-29317431

Assuntos

Proteína Forkhead Box O1/genética; Proteína Forkhead Box O3/genética; Cardiopatias/genética; Lamina Tipo A/genética; Terapêutica com RNAi/métodos; Animais; Apoptose; Células Cultivadas; Proteína Forkhead Box O1/metabolismo; Proteína Forkhead Box O3/metabolismo; Cardiopatias/terapia; Lamina Tipo A/deficiência; Camundongos; Miocárdio/metabolismo; Fenótipo

Palavras-chave

forkhead transcription factors; gene ontology; genetic therapy; transcription factors; transcriptome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lamina Tipo A / Terapêutica com RNAi / Proteína Forkhead Box O3 / Proteína Forkhead Box O1 / Cardiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Circ Res Ano de publicação: 2018 Tipo de documento: Article

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