Real-time polymerase chain reaction in acute retinal necrosis following encephalitis.
Indian J Ophthalmol
; 66(2): 322-324, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29380794
ABSTRACT
Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome. With continued treatment with intravenous acyclovir and intravitreal ganciclovir, the retinitis healed and the qPCR confirmed a reduction in the viral load. qPCR has a high sensitivity and specificity for HSV and is a useful tool for diagnosis and treatment of viral retinitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Humor Aquoso
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DNA Viral
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Infecções Oculares Virais
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Síndrome de Necrose Retiniana Aguda
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Herpesvirus Humano 1
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Reação em Cadeia da Polimerase em Tempo Real
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Indian J Ophthalmol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia