Parvovirus B19-associated Hemophagocytic Lymphohistiocytosis in a Patient With Glucose-6-phosphate Dehydrogenase Deficiency.

Zeckanovic, Aida; Perovnik, Matej; Jazbec, Janez; Petrovec, Miroslav; Pokorn, Marko; Kavcic, Marko

Zeckanovic, Aida; Perovnik, Matej; Jazbec, Janez; Petrovec, Miroslav; Pokorn, Marko; Kavcic, Marko.

Afiliação

Zeckanovic A; Faculty of Medicine, University of Ljubljana.
Perovnik M; Faculty of Medicine, University of Ljubljana.
Jazbec J; Department for Pediatric Hematology and Oncology, University Children's Hospital of Ljubljana.
Petrovec M; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana.
Pokorn M; Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Kavcic M; Department for Pediatric Hematology and Oncology, University Children's Hospital of Ljubljana.

J Pediatr Hematol Oncol ; 40(8): e550-e552, 2018 11.

Article em En | MEDLINE | ID: mdl-29432306

ABSTRACT

ABSTRACT

We report a case of a 12-year-old male with glucose-6-phosphate dehydrogenase deficiency presenting with clinical signs of sepsis and pancytopenia. Investigations revealed parvovirus B19 (PVB19)-associated hemophagocytic lymphohistiocytosis (HLH). The patient recovered fully and quickly with symptomatic treatment. Current evidence suggests that PVB19-associated HLH has a favorable prognosis. Mild undiagnosed cases of HLH may be the cause of pancytopenia in PVB19 infections.

Assuntos

Deficiência de Glucosefosfato Desidrogenase; Linfo-Histiocitose Hemofagocítica; Infecções por Parvoviridae; Parvovirus B19 Humano; Criança; Deficiência de Glucosefosfato Desidrogenase/genética; Deficiência de Glucosefosfato Desidrogenase/patologia; Deficiência de Glucosefosfato Desidrogenase/terapia; Humanos; Linfo-Histiocitose Hemofagocítica/diagnóstico; Linfo-Histiocitose Hemofagocítica/genética; Linfo-Histiocitose Hemofagocítica/patologia; Linfo-Histiocitose Hemofagocítica/terapia; Masculino; Infecções por Parvoviridae/diagnóstico; Infecções por Parvoviridae/genética; Infecções por Parvoviridae/patologia; Infecções por Parvoviridae/terapia; Sepse/diagnóstico; Sepse/genética; Sepse/patologia; Sepse/terapia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Parvovirus B19 Humano / Infecções por Parvoviridae / Linfo-Histiocitose Hemofagocítica / Deficiência de Glucosefosfato Desidrogenase Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2018 Tipo de documento: Article

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