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18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management.
Kommidi, Harikrishna; Guo, Hua; Nurili, Fuad; Vedvyas, Yogindra; Jin, Moonsoo M; McClure, Timothy D; Ehdaie, Behfar; Sayman, Haluk B; Akin, Oguz; Aras, Omer; Ting, Richard.
Afiliação
  • Kommidi H; Department of Radiology, Molecular Imaging Innovations Institute , Weill Cornell Medicine , New York , New York 10065 , United States.
  • Guo H; Department of Radiology, Molecular Imaging Innovations Institute , Weill Cornell Medicine , New York , New York 10065 , United States.
  • Nurili F; Department of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
  • Vedvyas Y; Department of Radiology, Molecular Imaging Innovations Institute , Weill Cornell Medicine , New York , New York 10065 , United States.
  • Jin MM; Department of Radiology, Molecular Imaging Innovations Institute , Weill Cornell Medicine , New York , New York 10065 , United States.
  • McClure TD; Department of Urology , Weill Cornell Medicine , New York , New York 10065 , United States.
  • Ehdaie B; Urology Service, Department of Surgery , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
  • Sayman HB; Department of Nuclear Medicine, Cerrahpasa Medical Faculty , Istanbul University , Fatih, Istanbul 34303 , Turkey.
  • Akin O; Department of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
  • Aras O; Department of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
  • Ting R; Department of Radiology, Molecular Imaging Innovations Institute , Weill Cornell Medicine , New York , New York 10065 , United States.
J Med Chem ; 61(9): 4256-4262, 2018 05 10.
Article em En | MEDLINE | ID: mdl-29676909
ABSTRACT
[18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/µmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Carbocianinas / Radioisótopos de Flúor / Meios de Contraste / Tomografia por Emissão de Pósitrons / Elétrons Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Carbocianinas / Radioisótopos de Flúor / Meios de Contraste / Tomografia por Emissão de Pósitrons / Elétrons Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos