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Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.
Tharakaraman, Kannan; Watanabe, Satoru; Chan, Kuan Rong; Huan, Jia; Subramanian, Vidya; Chionh, Yok Hian; Raguram, Aditya; Quinlan, Devin; McBee, Megan; Ong, Eugenia Z; Gan, Esther S; Tan, Hwee Cheng; Tyagi, Anu; Bhushan, Shashi; Lescar, Julien; Vasudevan, Subhash G; Ooi, Eng Eong; Sasisekharan, Ram.
Afiliação
  • Tharakaraman K; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • Watanabe S; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Chan KR; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Huan J; School of Biological Sciences and Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
  • Subramanian V; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • Chionh YH; Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology, Singapore, Singapore.
  • Raguram A; Harvard College, Harvard University, Cambridge, MA 02138, USA.
  • Quinlan D; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • McBee M; Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology, Singapore, Singapore.
  • Ong EZ; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Gan ES; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Tan HC; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Tyagi A; School of Biological Sciences and Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
  • Bhushan S; School of Biological Sciences and Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
  • Lescar J; School of Biological Sciences and Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
  • Vasudevan SG; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
  • Ooi EE; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore; Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology, Singapore, Singapore. Electronic address: engeong.ooi@duke-nus.edu.
  • Sasisekharan R; Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology, Singapore, Singap
Cell Host Microbe ; 23(5): 618-627.e6, 2018 05 09.
Article em En | MEDLINE | ID: mdl-29746833
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Anticorpos Neutralizantes / Zika virus / Infecção por Zika virus / Anticorpos Antivirais / Epitopos Limite: Animals / Pregnancy Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Anticorpos Neutralizantes / Zika virus / Infecção por Zika virus / Anticorpos Antivirais / Epitopos Limite: Animals / Pregnancy Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos