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Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Sudom, Athena; Talreja, Santosh; Danao, Jean; Bragg, Eric; Kegel, Rob; Min, Xiaoshan; Richardson, Jason; Zhang, Zhongqi; Sharkov, Nikolai; Marcora, Edoardo; Thibault, Steve; Bradley, Jodi; Wood, Steve; Lim, Ai-Ching; Chen, Hang; Wang, Songli; Foltz, Ian N; Sambashivan, Shilpa; Wang, Zhulun.
Afiliação
  • Sudom A; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080, asudom@amgen.com.
  • Talreja S; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Danao J; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Bragg E; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Kegel R; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Min X; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Richardson J; Amgen Discovery Research, Amgen Inc., Thousand Oaks, California 91320, and.
  • Zhang Z; Amgen Discovery Research, Amgen Inc., Thousand Oaks, California 91320, and.
  • Sharkov N; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Marcora E; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Thibault S; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Bradley J; Amgen Discovery Research, Amgen Inc., Thousand Oaks, California 91320, and.
  • Wood S; Amgen Discovery Research, Amgen Inc., Thousand Oaks, California 91320, and.
  • Lim AC; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Chen H; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Wang S; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080.
  • Foltz IN; Amgen Discovery Research, Amgen Inc., Burnaby, British Columbia V5A 1V7, Canada.
  • Sambashivan S; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080, shilpashivan@gmail.com.
  • Wang Z; From Amgen Discovery Research, Amgen Inc., San Francisco, California 94080, zwang@amgen.com.
J Biol Chem ; 293(32): 12634-12646, 2018 08 10.
Article em En | MEDLINE | ID: mdl-29794134
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Predisposição Genética para Doença / Proteínas Mutantes / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Predisposição Genética para Doença / Proteínas Mutantes / Doença de Alzheimer Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article