Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats.

Daniels, Lorna J; Wallace, Rachel S; Nicholson, Olivia M; Wilson, Genevieve A; McDonald, Fiona J; Jones, Peter P; Baldi, J Chris; Lamberts, Regis R; Erickson, Jeffrey R

Daniels, Lorna J; Wallace, Rachel S; Nicholson, Olivia M; Wilson, Genevieve A; McDonald, Fiona J; Jones, Peter P; Baldi, J Chris; Lamberts, Regis R; Erickson, Jeffrey R.

Afiliação

Daniels LJ; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Wallace RS; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Nicholson OM; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Wilson GA; Otago School of Medical Sciences, Department of Medicine and HeartOtago, University of Otago, Dunedin, New Zealand.
McDonald FJ; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Jones PP; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Baldi JC; Otago School of Medical Sciences, Department of Medicine and HeartOtago, University of Otago, Dunedin, New Zealand.
Lamberts RR; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand.
Erickson JR; Otago School of Medical Sciences, Department of Physiology and HeartOtago, University of Otago, 270 Great King Street, Dunedin, 9016, New Zealand. jeff.erickson@otago.ac.nz.

Cardiovasc Diabetol ; 17(1): 89, 2018 06 14.

Article em En | MEDLINE | ID: mdl-29903013

Assuntos

Benzilaminas/farmacologia; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/antagonistas & inibidores; Diabetes Mellitus Tipo 2/tratamento farmacológico; Cardiomiopatias Diabéticas/tratamento farmacológico; Contração Miocárdica/efeitos dos fármacos; Miocárdio/enzimologia; Peptídeos/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Sulfonamidas/farmacologia; Idoso; Animais; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Estudos de Casos e Controles; Diabetes Mellitus Tipo 2/enzimologia; Diabetes Mellitus Tipo 2/fisiopatologia; Cardiomiopatias Diabéticas/enzimologia; Cardiomiopatias Diabéticas/fisiopatologia; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Fosforilação; Ratos Zucker

Palavras-chave

Calcium/calmodulin-dependent kinase II; Cardiac contractility; Diabetes mellitus; Diabetic cardiac dysfunction; Echocardiography

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Sulfonamidas / Benzilaminas / Inibidores de Proteínas Quinases / Diabetes Mellitus Tipo 2 / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Cardiomiopatias Diabéticas / Contração Miocárdica / Miocárdio Tipo de estudo: Observational_studies Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Diabetol Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / ENDOCRINOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Nova Zelândia

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