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Survival and tolerance to sorafenib in Child-Pugh B patients with hepatocellular carcinoma: a prospective study.
Leal, Cassia Regina Guedes; Magalhães, Cristiane; Barbosa, Daniel; Aquino, Diogo; Carvalho, Bernardo; Balbi, Elizabeth; Pacheco, Lucio; Perez, Renata; de Tarso Pinto, Paulo; Setubal, Sérgio.
Afiliação
  • Leal CRG; Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Saúde, Rio de Janeiro, RJ, 20221-903, Brazil. cassia.r.g.leal@gmail.com.
  • Magalhães C; Universidade Federal Fluminense, Niterói, Brazil. cassia.r.g.leal@gmail.com.
  • Barbosa D; Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil.
  • Aquino D; Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Saúde, Rio de Janeiro, RJ, 20221-903, Brazil.
  • Carvalho B; Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Saúde, Rio de Janeiro, RJ, 20221-903, Brazil.
  • Balbi E; Hospital Federal dos Servidores do Estado, Rua Sacadura Cabral, 178, Saúde, Rio de Janeiro, RJ, 20221-903, Brazil.
  • Pacheco L; Hospital Quinta D'Or, Rio de Janeiro, Brazil.
  • Perez R; Hospital Quinta D'Or, Rio de Janeiro, Brazil.
  • de Tarso Pinto P; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Setubal S; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil.
Invest New Drugs ; 36(5): 911-918, 2018 10.
Article em En | MEDLINE | ID: mdl-29948358
Sorafenib has been widely used to treat unresectable hepatocellular carcinoma (HCC) but most studies have been done in Child-Pugh A (CP-A) patients with well-preserved liver function. We evaluated the overall survival (OS) and tolerance to sorafenib in a large cohort of Child-Pugh B (CP-B) HCC patients as compared to CP-A HCC patients. We prospectively studied 130 patients with advanced HCC who started sorafenib between January 2011 and December 2015. Patients were classified as CP-A (n = 65) or CP-B (n = 65). The average OS for all 130 patients was 10 months. CP-A patients had a median survival rate significantly longer than CP-B patients: 12 months vs. 6 months. The OS found in our group of CP-B patients was 6.5 months, which is higher than that found in most studies done so far. When stratified, our CP-B patients had better OS than ever reported. The dose of the drug was interrupted due to adverse events (AEs) in 38 (29%) of the patients, of whom 20 (30%) were CP-A patients and 18 (28%) were CP-B patients. This real-life cohort of CP-B HCC patients treated with sorafenib had a higher survival than that described in the literature, with a satisfactory safety profile. Despite the high prevalence of severe AEs in CP-B patients, there were fewer treatment interruptions in this group, indicating that Child-Pugh B patients can tolerate treatment and may benefit from sorafenib.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Inibidores de Proteínas Quinases / Sorafenibe / Neoplasias Hepáticas / Antineoplásicos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Inibidores de Proteínas Quinases / Sorafenibe / Neoplasias Hepáticas / Antineoplásicos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil