Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.

Lu, I-Ling; Chen, Chien; Tung, Chien-Yi; Chen, Hsin-Hung; Pan, Jia-Ping; Chang, Chia-Hsiang; Cheng, Jia-Shing; Chen, Yi-An; Wang, Chun-Hung; Huang, Chia-Wei; Kang, Yi-Ning; Chang, Hsin-Yun; Li, Lei-Li; Chang, Kai-Ping; Shih, Yang-Hsin; Lin, Chi-Hung; Kwan, Shang-Yeong; Tsai, Jin-Wu

Lu, I-Ling; Chen, Chien; Tung, Chien-Yi; Chen, Hsin-Hung; Pan, Jia-Ping; Chang, Chia-Hsiang; Cheng, Jia-Shing; Chen, Yi-An; Wang, Chun-Hung; Huang, Chia-Wei; Kang, Yi-Ning; Chang, Hsin-Yun; Li, Lei-Li; Chang, Kai-Ping; Shih, Yang-Hsin; Lin, Chi-Hung; Kwan, Shang-Yeong; Tsai, Jin-Wu.

Afiliação

Lu IL; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Chen C; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Tung CY; National Yang-Ming University School of Medicine, Taipei, 112, Taiwan.
Chen HH; VYM Genome Research Center of National Yang-Ming University, Taipei, 112, Taiwan.
Pan JP; Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, 112, Taiwan.
Chang CH; National Yang-Ming University School of Medicine, Taipei, 112, Taiwan.
Cheng JS; Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Chen YA; VYM Genome Research Center of National Yang-Ming University, Taipei, 112, Taiwan.
Wang CH; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Huang CW; Taiwan International Graduate Program (TIGP) in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, 112, Taiwan.
Kang YN; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Chang HY; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Li LL; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Chang KP; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Shih YH; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Lin CH; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Kwan SY; Institute of Brain Science, National Yang-Ming University, Taipei, 112, Taiwan.
Tsai JW; National Yang-Ming University School of Medicine, Taipei, 112, Taiwan.

Nat Commun ; 9(1): 2498, 2018 06 27.

Article em En | MEDLINE | ID: mdl-29950674

Assuntos

Córtex Cerebral/anormalidades; Epilepsia/genética; Testes Genéticos/métodos; Malformações do Desenvolvimento Cortical do Grupo I/genética; Neurônios/patologia; Adolescente; Adulto; Animais; Biomarcadores/análise; Sistemas CRISPR-Cas; Córtex Cerebral/citologia; Córtex Cerebral/diagnóstico por imagem; Córtex Cerebral/patologia; Criança; Pré-Escolar; Elementos de DNA Transponíveis/genética; Modelos Animais de Doenças; Epilepsia/diagnóstico; Epilepsia/patologia; Feminino; Neuroimagem Funcional; Técnicas de Silenciamento de Genes; Humanos; Masculino; Malformações do Desenvolvimento Cortical do Grupo I/diagnóstico; Malformações do Desenvolvimento Cortical do Grupo I/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos ICR; Mutagênese/genética; Mutação; Interferência de RNA; RNA Interferente Pequeno/metabolismo; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Testes Genéticos / Epilepsia / Malformações do Desenvolvimento Cortical do Grupo I / Neurônios Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Taiwan

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