The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus.
Nucleic Acids Res
; 46(17): 8803-8816, 2018 09 28.
Article
em En
| MEDLINE
| ID: mdl-29986060
ABSTRACT
RsaE is a regulatory RNA highly conserved amongst Firmicutes that lowers the amount of mRNAs associated with the TCA cycle and folate metabolism. A search for new RsaE targets in Staphylococcus aureus revealed that in addition to previously described substrates, RsaE down-regulates several genes associated with arginine catabolism. In particular, RsaE targets the arginase rocF mRNA via direct interactions involving G-rich motifs. Two duplicated C-rich motifs of RsaE can independently downregulate rocF expression. The faster growth rate of ΔrsaE compared to its parental strain in media containing amino acids as sole carbon source points to an underlying role for RsaE in amino acid catabolism. Collectively, the data support a model in which RsaE acts as a global regulator of functions associated with metabolic adaptation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arginina
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Staphylococcus aureus
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RNA Bacteriano
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Sequências Reguladoras de Ácido Ribonucleico
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França