Unexpected Growth-Promoting Effect of Oxaliplatin in Excision Repair Cross-Complementation Group 1 Transfected Human Colon Cancer Cells.
Pharmacology
; 102(3-4): 161-168, 2018.
Article
em En
| MEDLINE
| ID: mdl-30048976
ABSTRACT
The nucleotide excision repair protein excision repair cross-complementation group 1 (ERCC1) has been repeatedly shown to be involved in the sensitivity of cancer cells to platinum derivatives. In order to better understand this process, we transfected HCT-116 cells with a plasmid encoding ERCC1 and studied their in vitro and in vivo behaviour. No main differences were observed for sensitivity to platinum drugs, DNA repair capacity and clonogenicity in vitro. However, -ERCC1-transfected HCT-116 cells showed paradoxical behaviour in vivo with increased growth in mice treated with oxaliplatin as compared to untreated mice. The Trop2 protein was identified as being potentially involved in the underlying mechanism for these observations, as it was overexpressed in transfected cells. Our results suggest complex regulation of signalling in cancer cells exposed to cancer drugs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organoplatínicos
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Neoplasias Colorretais
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Proteínas de Ligação a DNA
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Endonucleases
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Antineoplásicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Pharmacology
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França