Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic ß cells apoptosis and dysfunction.

Wang, Yue; Liu, Quan; Huan, Yi; Li, Rongcui; Li, Caina; Sun, Sujuan; Guo, Nan; Yang, Miaomiao; Liu, Shuainan; Shen, Zhufang

Wang, Yue; Liu, Quan; Huan, Yi; Li, Rongcui; Li, Caina; Sun, Sujuan; Guo, Nan; Yang, Miaomiao; Liu, Shuainan; Shen, Zhufang.

Afiliação

Wang Y; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Liu Q; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Huan Y; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Li R; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Li C; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Sun S; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Guo N; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Yang M; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Liu S; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing
Shen Z; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key laboratory of Polymorphic Drugs of Beijing, Diabetes Research Center of Chinese Academy of Medical Sciences, Beijing

Exp Cell Res ; 371(1): 205-213, 2018 10 01.

Article em En | MEDLINE | ID: mdl-30098330

Assuntos

Diabetes Mellitus Experimental/genética; Regulação da Expressão Gênica; Glucose/metabolismo; Células Secretoras de Insulina/metabolismo; Mitocôndrias/metabolismo; Sirtuínas/genética; Animais; Apoptose/efeitos dos fármacos; Apoptose/genética; Caspase 3/genética; Caspase 3/metabolismo; Linhagem Celular; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Glucose/farmacologia; Humanos; Insulina/metabolismo; Células Secretoras de Insulina/efeitos dos fármacos; Células Secretoras de Insulina/patologia; Malondialdeído/metabolismo; Camundongos; Mitocôndrias/efeitos dos fármacos; Ácido Palmítico/farmacologia; Proteínas Proto-Oncogênicas c-bcl-2/genética; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Ratos; Transdução de Sinais; Sirtuínas/metabolismo; Proteína X Associada a bcl-2/genética; Proteína X Associada a bcl-2/metabolismo; Proteína de Morte Celular Associada a bcl/genética; Proteína de Morte Celular Associada a bcl/metabolismo; Proteína bcl-X/genética; Proteína bcl-X/metabolismo

Palavras-chave

Apoptosis; Glucolipotoxicity; Insulin secretion; SIRT5; ß cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Sirtuínas / Diabetes Mellitus Experimental / Células Secretoras de Insulina / Glucose / Mitocôndrias Limite: Animals / Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2018 Tipo de documento: Article

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