A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts.

Jonsson, Malin K B; Hartman, Robin J G; Ackers-Johnson, Matthew; Tan, Wilson L W; Lim, Bing; van Veen, Toon A B; Foo, Roger S

A Transcriptomic and Epigenomic Comparison of Fetal and Adult Human Cardiac Fibroblasts Reveals Novel Key Transcription Factors in Adult Cardiac Fibroblasts.

Jonsson, Malin K B; Hartman, Robin J G; Ackers-Johnson, Matthew; Tan, Wilson L W; Lim, Bing; van Veen, Toon A B; Foo, Roger S.

Afiliação

Jonsson MKB; Human Genetics, Genome Institute of Singapore, Singapore.
Hartman RJG; Human Genetics, Genome Institute of Singapore, Singapore.
Ackers-Johnson M; University of Utrecht, Utrecht, the Netherlands.
Tan WLW; Human Genetics, Genome Institute of Singapore, Singapore.
Lim B; Cardiovascular Research Institute, National University Health Systems, National University of Singapore, Singapore.
van Veen TAB; Human Genetics, Genome Institute of Singapore, Singapore.
Foo RS; Cardiovascular Research Institute, National University Health Systems, National University of Singapore, Singapore.

JACC Basic Transl Sci ; 1(7): 590-602, 2016 Dec.

Article em En | MEDLINE | ID: mdl-30167544

Palavras-chave

ATAC, assay for transposase accessible chromatin; ATAC-seq, assay for transposase accessible chromatinsequencing; CF, cardiac fibroblast; CM, cardiomyocyte; ChIP-seq, chromatin immunoprecipitationsequencing; ECM, extracellular matrix; EMT, epithelial-to-mesenchymal transformation; FGF, fibroblast growth factor; HCF, human cardiac fibroblast; IL, interleukin; IPA, Ingenuity Pathway Analysis; RNA-seq, ribonucleic acidsequencing; RT-qPCR, reverse transcriptionquantitative polymerase chain reaction; TF, transcription factor; aHCF, adult human cardiac fibroblast; cardiac fibroblasts; collagen; fHCF, fetal human cardiac fibroblast; histone methylation; transcriptome

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Singapura

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