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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Tsagris, Denise J; Birchall, Kristian; Bouloc, Nathalie; Large, Jonathan M; Merritt, Andy; Smiljanic-Hurley, Ela; Wheldon, Mary; Ansell, Keith H; Kettleborough, Catherine; Whalley, David; Stewart, Lindsay B; Bowyer, Paul W; Baker, David A; Osborne, Simon A.
Afiliação
  • Tsagris DJ; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK. Electronic address: denise.tsagris@lifearc.org.
  • Birchall K; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Bouloc N; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Large JM; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Merritt A; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Smiljanic-Hurley E; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Wheldon M; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Ansell KH; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Kettleborough C; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Whalley D; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
  • Stewart LB; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Bowyer PW; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Baker DA; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
  • Osborne SA; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.
Bioorg Med Chem Lett ; 28(19): 3168-3173, 2018 10 15.
Article em En | MEDLINE | ID: mdl-30174152
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Tiazóis / Proteínas de Protozoários / Proteínas Quinases Dependentes de GMP Cíclico / Inibidores de Proteínas Quinases / Antimaláricos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Tiazóis / Proteínas de Protozoários / Proteínas Quinases Dependentes de GMP Cíclico / Inibidores de Proteínas Quinases / Antimaláricos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article