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6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to ß-Estradiol.
Lapham, Kimberly; Lin, Jian; Novak, Jonathan; Orozco, Christine; Niosi, Mark; Di, Li; Goosen, Theunis C; Ryu, Sangwoo; Riccardi, Keith; Eng, Heather; Cameron, Kimberly O; Kalgutkar, Amit S.
Afiliação
  • Lapham K; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.) amit.kalgutkar@pfizer.com kimberly.lapham@pfizer.com.
  • Lin J; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Novak J; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Orozco C; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Niosi M; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Di L; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Goosen TC; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Ryu S; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Riccardi K; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Eng H; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Cameron KO; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.).
  • Kalgutkar AS; Medicine Design, Pfizer Inc., Groton, Connecticut (K.L., J.L., J.N., C.O., M.N., L.D., T.C.G., S.R., K.R., H.E.); and Medicine Design, Pfizer Inc., Cambridge, Massachusetts (K.O.C., A.S.K.) amit.kalgutkar@pfizer.com kimberly.lapham@pfizer.com.
Drug Metab Dispos ; 46(12): 1836-1846, 2018 12.
Article em En | MEDLINE | ID: mdl-30194276
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Glucuronídeos / Estradiol / Indóis / Microssomos Limite: Female / Humans / Male Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glucuronosiltransferase / Glucuronídeos / Estradiol / Indóis / Microssomos Limite: Female / Humans / Male Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article